Predicted to act upstream of or within hematopoietic progenitor cell differentiation. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZSWIM9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSWIM9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSWIM9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:47,891,593–47,892,745 | 278.4 kb | Distal (>10kb) Multiome | 522 | |
| chr19:48,169,480–48,171,282 | 207 bp | At TSS Multiome | 950 | |
| chr19:48,203,709–48,204,551 | 33.4 kb | Distal (>10kb) Multiome | 741 | |
| chr19:48,271,198–48,272,050 | 100.9 kb | Distal (>10kb) Multiome | 562 | |
| chr19:48,290,181–48,291,716 | 120.1 kb | Distal (>10kb) Multiome | 666 | |
| chr19:48,320,062–48,322,328 | 150.8 kb | Distal (>10kb) Multiome | 826 | |
| chr19:48,330,094–48,330,787 | 159.6 kb | Distal (>10kb) Multiome | 460 | |
| chr19:48,332,701–48,333,506 | 162.2 kb | Distal (>10kb) Multiome | 615 | |
| chr19:48,333,584–48,334,372 | 163.4 kb | Distal (>10kb) Multiome | 554 | |
| chr19:48,363,062–48,364,710 | 193.5 kb | Distal (>10kb) Multiome | 940 | |
| chr19:48,390,663–48,391,935 | 220.9 kb | Distal (>10kb) Multiome | 816 | |
| chr19:48,397,916–48,399,301 | 228.2 kb | Distal (>10kb) Multiome | 619 | |
| chr19:48,399,411–48,400,900 | 229.9 kb | Distal (>10kb) Multiome | 548 | |
| chr19:48,414,121–48,416,085 | 244.9 kb | Distal (>10kb) Multiome | 298 | |
| chr19:48,445,379–48,446,456 | 275.2 kb | Distal (>10kb) Multiome | 845 | |
| chr19:48,468,758–48,470,027 | 298.5 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the ZSWIM9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.