Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZSCAN5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSCAN5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSCAN5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:56,120,040–56,122,160 | 193.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr19:56,140,231–56,141,860 | 173.5 kb | Distal (>10kb) Multiome | 744 | |
| chr19:56,217,208–56,217,951 | 96.9 kb | Distal (>10kb) Multiome | 116 | |
| chr19:56,309,629–56,309,880 | 4.6 kb | Proximal (<10kb) | 302 | |
| chr19:56,314,052–56,315,623 | 497 bp | At TSS Multiome | 844 | |
| chr19:56,346,962–56,347,557 | 32.8 kb | Distal (>10kb) Multiome | 97 | |
| chr19:56,367,790–56,368,666 | 53.7 kb | Distal (>10kb) Multiome | 609 | |
| chr19:56,393,166–56,393,951 | 79.0 kb | Distal (>10kb) Multiome | 653 | |
| chr19:56,403,714–56,404,765 | 89.7 kb | Distal (>10kb) Multiome | 745 | |
| chr19:56,566,944–56,568,046 | 253.0 kb | Distal (>10kb) Multiome | 436 | |
| chr19:56,594,882–56,595,857 | 280.8 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the ZSCAN5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.