The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZSCAN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSCAN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSCAN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,570,159–84,571,300 | 30.1 kb | Distal (>10kb) Multiome | 730 | |
| chr15:84,587,808–84,588,502 | 12.9 kb | Distal (>10kb) Multiome | 357 | |
| chr15:84,600,331–84,601,554 | 79 bp | At TSS Multiome | 827 | |
| chr15:84,603,386–84,604,192 | 2.7 kb | Proximal (<10kb) Multiome | 119 | |
| chr15:84,630,983–84,631,898 | 30.3 kb | Distal (>10kb) Multiome | 649 | |
| chr15:84,633,275–84,634,337 | 32.7 kb | Distal (>10kb) Multiome | 621 | |
| chr15:84,653,715–84,654,595 | 53.3 kb | Distal (>10kb) Multiome | 788 | |
| chr15:84,657,788–84,658,916 | 57.3 kb | Distal (>10kb) Multiome | 591 | |
| chr15:84,715,472–84,717,226 | 115.3 kb | Distal (>10kb) Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 134.1 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 147.4 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 216.7 kb | Distal (>10kb) Multiome | 375 |
Genomic view of the ZSCAN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.