Enables ubiquitin protein ligase activity. Involved in positive regulation of autophagosome-lysosome fusion. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. Is active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ZNRF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNRF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNRF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:29,988,902–29,990,326 | 294.8 kb | Distal (>10kb) Multiome | 631 | |
| chr7:30,026,273–30,027,418 | 257.8 kb | Distal (>10kb) Multiome | 750 | |
| chr7:30,027,667–30,029,334 | 256.2 kb | Distal (>10kb) Multiome | 888 | |
| chr7:30,134,508–30,136,317 | 149.8 kb | Distal (>10kb) Multiome | 663 | |
| chr7:30,276,170–30,276,400 | 8.2 kb | Proximal (<10kb) | 168 | |
| chr7:30,281,343–30,281,575 | 3.0 kb | Proximal (<10kb) | 43 | |
| chr7:30,284,014–30,286,043 | 91 bp | At TSS Multiome | 943 | |
| chr7:30,472,499–30,473,444 | 188.3 kb | Distal (>10kb) Multiome | 123 | |
| chr7:30,478,426–30,479,128 | 194.1 kb | Distal (>10kb) Multiome | 756 | |
| chr7:30,504,202–30,505,455 | 220.3 kb | Distal (>10kb) Multiome | 824 | |
| chr7:30,544,196–30,544,698 | 259.9 kb | Distal (>10kb) Multiome | 40 |
Genomic view of the ZNRF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.