This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for ZNF821. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF821 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF821, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,625,835–71,627,289 | 258.0 kb | Distal (>10kb) Multiome | 594 | |
| chr16:71,722,829–71,724,442 | 161.0 kb | Distal (>10kb) Multiome | 894 | |
| chr16:71,808,251–71,809,603 | 75.0 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:71,845,428–71,846,392 | 38.2 kb | Distal (>10kb) Multiome | 923 | |
| chr16:71,882,508–71,882,667 | 1.5 kb | Proximal (<10kb) | 313 | |
| chr16:71,883,009–71,884,742 | 22 bp | At TSS Multiome | 791 | |
| chr16:71,890,687–71,891,083 | 6.5 kb | Proximal (<10kb) | 114 | |
| chr16:71,894,288–71,896,022 | 11.2 kb | Distal (>10kb) Multiome | 1139 | |
| chr16:71,981,752–71,982,390 | 97.9 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,008,426–72,009,172 | 124.5 kb | Distal (>10kb) Multiome | 815 | |
| chr16:72,013,585–72,014,228 | 129.9 kb | Distal (>10kb) Multiome HiCAR | 263 | |
| chr16:72,093,288–72,094,355 | 209.6 kb | Distal (>10kb) Multiome | 860 | |
| chr16:72,111,833–72,112,319 | 228.0 kb | Distal (>10kb) Multiome | 60 |
Genomic view of the ZNF821 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.