Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF730. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF730 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF730, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:23,074,842–23,075,882 | 101 bp | At TSS Multiome | 399 | |
| chr19:23,077,484–23,078,251 | 2.3 kb | Proximal (<10kb) | 16 | |
| chr19:23,116,566–23,117,541 | 41.8 kb | Distal (>10kb) Multiome | 257 | |
| chr19:23,203,789–23,204,323 | 128.8 kb | Distal (>10kb) Multiome | 53 | |
| chr19:23,249,247–23,251,013 | 175.2 kb | Distal (>10kb) Multiome | 457 | |
| chr19:23,254,024–23,254,900 | 179.3 kb | Distal (>10kb) Multiome | 62 | |
| chr19:23,273,473–23,274,442 | 198.9 kb | Distal (>10kb) Multiome | 565 | |
| chr19:23,277,685–23,278,396 | 202.8 kb | Distal (>10kb) Multiome | 71 | |
| chr19:23,686,411–23,687,441 | 611.9 kb | Distal (>10kb) Multiome HiCAR | 490 | |
| chr19:23,762,593–23,763,893 | 687.8 kb | Distal (>10kb) Multiome HiCAR | 429 | |
| chr19:24,033,224–24,034,370 | 958.3 kb | Distal (>10kb) Multiome HiCAR | 673 | |
| chr19:24,086,718–24,087,708 | 1012.0 kb | Distal (>10kb) Multiome HiCAR | 390 |
Genomic view of the ZNF730 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.