Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within lipid metabolic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF670. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF670 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF670, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:246,931,032–246,932,682 | 146.7 kb | Distal (>10kb) Multiome | 1007 | |
| chr1:247,007,420–247,008,623 | 70.7 kb | Distal (>10kb) Multiome | 629 | |
| chr1:247,078,252–247,079,771 | 17 bp | At TSS Multiome | 817 | |
| chr1:247,082,766–247,083,164 | 4.0 kb | Proximal (<10kb) | 6 | |
| chr1:247,089,108–247,090,336 | 10.9 kb | Distal (>10kb) Multiome | 197 | |
| chr1:247,103,830–247,105,264 | 25.6 kb | Distal (>10kb) Multiome | 878 | |
| chr1:247,110,957–247,112,601 | 33.4 kb | Distal (>10kb) Multiome | 790 | |
| chr1:247,118,927–247,119,515 | 40.3 kb | Distal (>10kb) Multiome | 252 | |
| chr1:247,210,163–247,211,257 | 132.0 kb | Distal (>10kb) Multiome | 764 | |
| chr1:247,330,646–247,333,480 | 253.1 kb | Distal (>10kb) Multiome | 839 | |
| chr1:247,347,704–247,348,357 | 269.2 kb | Distal (>10kb) Multiome | 165 | |
| chr1:247,356,823–247,358,156 | 278.4 kb | Distal (>10kb) Multiome | 296 | |
| chr1:247,376,539–247,377,867 | 298.1 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the ZNF670 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.