The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF638. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF638 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF638, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:70,976,676–70,977,663 | 299.3 kb | Distal (>10kb) Multiome | 372 | |
| chr2:70,978,404–70,979,416 | 297.6 kb | Distal (>10kb) Multiome | 229 | |
| chr2:70,994,406–70,995,235 | 281.6 kb | Distal (>10kb) Multiome | 805 | |
| chr2:71,067,597–71,069,479 | 208.1 kb | Distal (>10kb) Multiome | 1161 | |
| chr2:71,103,036–71,103,639 | 173.2 kb | Distal (>10kb) Multiome | 56 | |
| chr2:71,129,728–71,130,863 | 146.2 kb | Distal (>10kb) Multiome | 1092 | |
| chr2:71,226,288–71,227,849 | 49.3 kb | Distal (>10kb) Multiome | 657 | |
| chr2:71,276,206–71,277,158 | 29 bp | At TSS Multiome | 790 | |
| chr2:71,277,392–71,277,948 | 800 bp | At TSS | 278 | |
| chr2:71,331,200–71,332,517 | 55.2 kb | Distal (>10kb) Multiome | 920 | |
| chr2:71,336,610–71,336,824 | 4.9 kb | Proximal (<10kb) | 28 | |
| chr2:71,453,379–71,454,558 | 177.1 kb | Distal (>10kb) Multiome | 298 | |
| chr2:71,466,113–71,467,114 | 190.1 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the ZNF638 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.