Enables preribosome binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF622. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF622 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF622, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:15,499,582–15,501,921 | 965.6 kb | Distal (>10kb) Multiome HiCAR | 468 | |
| chr5:16,178,616–16,180,665 | 286.7 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr5:16,229,115–16,230,175 | 236.1 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr5:16,378,323–16,379,199 | 86.9 kb | Distal (>10kb) Multiome | 110 | |
| chr5:16,419,918–16,420,591 | 45.5 kb | Distal (>10kb) Multiome | 53 | |
| chr5:16,456,116–16,456,744 | 9.1 kb | Proximal (<10kb) | 204 | |
| chr5:16,465,184–16,466,419 | 77 bp | At TSS Multiome | 953 | |
| chr5:16,575,212–16,575,703 | 109.6 kb | Distal (>10kb) Multiome | 124 | |
| chr5:16,616,186–16,617,558 | 151.1 kb | Distal (>10kb) Multiome | 428 | |
| chr5:16,737,662–16,738,837 | 272.5 kb | Distal (>10kb) Multiome | 275 |
Genomic view of the ZNF622 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.