Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF621. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF621 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF621, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:40,291,090–40,292,047 | 233.3 kb | Distal (>10kb) Multiome | 87 | |
| chr3:40,308,903–40,310,435 | 215.3 kb | Distal (>10kb) Multiome | 940 | |
| chr3:40,386,652–40,387,704 | 137.8 kb | Distal (>10kb) Multiome | 280 | |
| chr3:40,452,726–40,453,738 | 71.7 kb | Distal (>10kb) Multiome | 787 | |
| chr3:40,456,939–40,457,754 | 67.6 kb | Distal (>10kb) Multiome | 794 | |
| chr3:40,476,853–40,477,451 | 47.8 kb | Distal (>10kb) Multiome | 534 | |
| chr3:40,505,545–40,506,480 | 19.0 kb | Distal (>10kb) Multiome | 700 | |
| chr3:40,524,355–40,525,405 | 92 bp | At TSS Multiome | 904 | |
| chr3:40,615,244–40,616,130 | 90.7 kb | Distal (>10kb) Multiome | 206 | |
| chr3:42,159,717–42,160,505 | 1635.1 kb | Distal (>10kb) Multiome HiCAR | 491 |
Genomic view of the ZNF621 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.