Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF616. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF616 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF616, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:51,904,568–51,905,180 | 235.0 kb | Distal (>10kb) Multiome | 662 | |
| chr19:51,926,700–51,927,523 | 212.8 kb | Distal (>10kb) Multiome | 675 | |
| chr19:51,960,144–51,961,162 | 179.2 kb | Distal (>10kb) Multiome | 242 | |
| chr19:52,007,532–52,008,736 | 131.7 kb | Distal (>10kb) Multiome | 704 | |
| chr19:52,026,275–52,027,092 | 113.2 kb | Distal (>10kb) Multiome | 153 | |
| chr19:52,027,979–52,028,972 | 111.4 kb | Distal (>10kb) Multiome | 837 | |
| chr19:52,048,367–52,049,488 | 91.0 kb | Distal (>10kb) Multiome | 711 | |
| chr19:52,138,651–52,138,980 | at TSS | At TSS | 273 | |
| chr19:52,139,087–52,140,222 | 44 bp | At TSS Multiome | 788 | |
| chr19:52,170,935–52,172,031 | 31.7 kb | Distal (>10kb) Multiome | 404 | |
| chr19:52,189,175–52,190,788 | 50.1 kb | Distal (>10kb) Multiome | 912 | |
| chr19:52,269,012–52,270,193 | 129.6 kb | Distal (>10kb) Multiome | 782 | |
| chr19:52,296,552–52,297,775 | 157.2 kb | Distal (>10kb) Multiome | 561 | |
| chr19:52,335,886–52,336,825 | 196.3 kb | Distal (>10kb) Multiome | 373 | |
| chr19:52,338,866–52,339,647 | 199.4 kb | Distal (>10kb) Multiome | 56 |
Genomic view of the ZNF616 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.