Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF589. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF589 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF589, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,088,196–48,089,485 | 152.0 kb | Distal (>10kb) Multiome | 933 | |
| chr3:48,187,500–48,188,989 | 52.6 kb | Distal (>10kb) Multiome | 820 | |
| chr3:48,232,758–48,233,011 | 8.1 kb | Proximal (<10kb) | 412 | |
| chr3:48,240,069–48,240,440 | 658 bp | At TSS | 150 | |
| chr3:48,240,728–48,241,473 | 23 bp | At TSS Multiome | 843 | |
| chr3:48,300,947–48,301,746 | 60.3 kb | Distal (>10kb) Multiome | 954 | |
| chr3:48,372,864–48,373,543 | 132.1 kb | Distal (>10kb) Multiome | 49 | |
| chr3:48,428,528–48,430,504 | 188.9 kb | Distal (>10kb) Multiome HiCAR | 910 | |
| chr3:48,439,801–48,440,548 | 199.1 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:48,446,396–48,447,180 | 205.7 kb | Distal (>10kb) Multiome HiCAR | 767 | |
| chr3:48,465,344–48,466,310 | 224.6 kb | Distal (>10kb) Multiome | 670 | |
| chr3:48,472,636–48,473,658 | 232.1 kb | Distal (>10kb) Multiome | 821 | |
| chr3:48,503,451–48,504,839 | 263.0 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the ZNF589 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.