Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF586. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF586 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF586, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,477,251–57,477,789 | 292.1 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 281.9 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 269.8 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 242.3 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 209.8 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 190.7 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 185.6 kb | Distal (>10kb) Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 169.8 kb | Distal (>10kb) Multiome | 646 | |
| chr19:57,614,049–57,614,534 | 155.4 kb | Distal (>10kb) Multiome | 661 | |
| chr19:57,632,786–57,633,679 | 136.5 kb | Distal (>10kb) Multiome | 652 | |
| chr19:57,681,556–57,682,393 | 87.7 kb | Distal (>10kb) Multiome | 724 | |
| chr19:57,708,682–57,709,450 | 60.5 kb | Distal (>10kb) Multiome | 199 | |
| chr19:57,727,326–57,727,941 | 42.0 kb | Distal (>10kb) Multiome | 400 | |
| chr19:57,746,610–57,747,111 | 22.8 kb | Distal (>10kb) Multiome | 625 | |
| chr19:57,769,422–57,770,058 | 2 bp | At TSS Multiome | 509 | |
| chr19:57,803,547–57,804,316 | 34.3 kb | Distal (>10kb) Multiome | 206 | |
| chr19:57,804,773–57,805,214 | 35.4 kb | Distal (>10kb) Multiome | 37 | |
| chr19:57,810,480–57,811,177 | 41.2 kb | Distal (>10kb) Multiome | 180 | |
| chr19:57,814,439–57,815,270 | 45.3 kb | Distal (>10kb) Multiome | 692 | |
| chr19:57,819,268–57,819,991 | 50.0 kb | Distal (>10kb) Multiome | 734 | |
| chr19:57,829,187–57,830,712 | 60.6 kb | Distal (>10kb) Multiome | 321 | |
| chr19:57,849,421–57,850,221 | 80.1 kb | Distal (>10kb) Multiome | 291 | |
| chr19:57,887,264–57,887,897 | 117.9 kb | Distal (>10kb) Multiome | 47 | |
| chr19:57,888,389–57,889,457 | 119.4 kb | Distal (>10kb) Multiome | 322 | |
| chr19:57,916,199–57,917,124 | 147.1 kb | Distal (>10kb) Multiome | 535 | |
| chr19:57,934,907–57,935,617 | 165.7 kb | Distal (>10kb) Multiome | 259 | |
| chr19:57,947,388–57,948,012 | 178.1 kb | Distal (>10kb) Multiome | 675 | |
| chr19:58,002,336–58,003,368 | 233.2 kb | Distal (>10kb) Multiome | 830 | |
| chr19:58,059,066–58,059,937 | 289.7 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the ZNF586 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.