Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF559. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF559 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF559, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,054,643–9,055,419 | 269.2 kb | Distal (>10kb) Multiome | 237 | |
| chr19:9,140,232–9,140,885 | 183.7 kb | Distal (>10kb) Multiome | 722 | |
| chr19:9,309,252–9,310,462 | 14.3 kb | Distal (>10kb) Multiome | 627 | |
| chr19:9,323,540–9,324,623 | 23 bp | At TSS Multiome | 577 | |
| chr19:9,435,095–9,435,909 | 111.4 kb | Distal (>10kb) Multiome | 701 | |
| chr19:9,538,339–9,539,009 | 214.5 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 258.3 kb | Distal (>10kb) Multiome | 99 | |
| chr19:9,584,055–9,584,863 | 260.4 kb | Distal (>10kb) Multiome | 801 | |
| chr19:9,620,792–9,622,027 | 297.1 kb | Distal (>10kb) Multiome | 856 |
Genomic view of the ZNF559 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.