Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF525. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF525 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF525, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,102,740–53,104,032 | 262.1 kb | Distal (>10kb) Multiome | 634 | |
| chr19:53,158,810–53,159,647 | 206.6 kb | Distal (>10kb) Multiome | 317 | |
| chr19:53,192,722–53,193,557 | 172.3 kb | Distal (>10kb) Multiome HiCAR | 285 | |
| chr19:53,196,790–53,197,387 | 168.7 kb | Distal (>10kb) Multiome HiCAR | 329 | |
| chr19:53,254,450–53,255,344 | 110.7 kb | Distal (>10kb) Multiome | 295 | |
| chr19:53,333,122–53,334,368 | 32.0 kb | Distal (>10kb) Multiome | 319 | |
| chr19:53,365,124–53,366,164 | 62 bp | At TSS Multiome | 346 | |
| chr19:53,394,512–53,395,775 | 29.3 kb | Distal (>10kb) Multiome | 453 | |
| chr19:53,431,377–53,432,626 | 66.2 kb | Distal (>10kb) Multiome | 522 | |
| chr19:53,463,129–53,463,807 | 97.7 kb | Distal (>10kb) Multiome | 104 | |
| chr19:53,467,122–53,469,090 | 102.0 kb | Distal (>10kb) Multiome | 381 | |
| chr19:53,520,353–53,521,485 | 155.2 kb | Distal (>10kb) Multiome | 700 | |
| chr19:53,537,348–53,538,212 | 172.1 kb | Distal (>10kb) Multiome | 623 | |
| chr19:53,594,477–53,595,909 | 229.6 kb | Distal (>10kb) Multiome | 262 | |
| chr19:53,612,802–53,613,443 | 247.2 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the ZNF525 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.