Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF496. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF496 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF496, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:247,078,252–247,079,771 | 253.1 kb | Distal (>10kb) Multiome | 817 | |
| chr1:247,089,108–247,090,336 | 242.1 kb | Distal (>10kb) Multiome | 197 | |
| chr1:247,103,830–247,105,264 | 227.5 kb | Distal (>10kb) Multiome | 878 | |
| chr1:247,110,957–247,112,601 | 219.7 kb | Distal (>10kb) Multiome | 790 | |
| chr1:247,118,927–247,119,515 | 212.7 kb | Distal (>10kb) Multiome | 252 | |
| chr1:247,210,163–247,211,257 | 121.0 kb | Distal (>10kb) Multiome | 764 | |
| chr1:247,330,646–247,333,480 | 54 bp | At TSS Multiome | 839 | |
| chr1:247,335,608–247,336,456 | 3.8 kb | Proximal (<10kb) | 78 | |
| chr1:247,347,704–247,348,357 | 16.2 kb | Distal (>10kb) Multiome | 165 | |
| chr1:247,356,823–247,358,156 | 25.4 kb | Distal (>10kb) Multiome | 296 | |
| chr1:247,376,539–247,377,867 | 45.1 kb | Distal (>10kb) Multiome | 164 | |
| chr1:247,389,944–247,390,543 | 58.5 kb | Distal (>10kb) Multiome | 451 | |
| chr1:247,448,083–247,448,740 | 116.5 kb | Distal (>10kb) Multiome | 246 | |
| chr1:248,857,587–248,859,802 | 1527.1 kb | Distal (>10kb) Multiome HiCAR | 984 | |
| chr1:248,862,776–248,863,977 | 1531.5 kb | Distal (>10kb) Multiome HiCAR | 625 | |
| chr1:248,872,599–248,874,733 | 1542.1 kb | Distal (>10kb) Multiome HiCAR | 1099 |
Genomic view of the ZNF496 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.