Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:43,639,490–43,640,467 | 295.4 kb | Distal (>10kb) Multiome | 545 | |
| chr19:43,667,574–43,669,430 | 266.6 kb | Distal (>10kb) Multiome | 787 | |
| chr19:43,671,889–43,672,687 | 263.0 kb | Distal (>10kb) Multiome | 162 | |
| chr19:43,673,253–43,674,111 | 261.4 kb | Distal (>10kb) Multiome | 55 | |
| chr19:43,754,239–43,755,900 | 180.5 kb | Distal (>10kb) Multiome | 899 | |
| chr19:43,773,845–43,774,908 | 160.7 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,798,557–43,799,046 | 136.4 kb | Distal (>10kb) Multiome | 403 | |
| chr19:43,827,133–43,827,702 | 107.9 kb | Distal (>10kb) Multiome | 593 | |
| chr19:43,901,409–43,901,966 | 33.5 kb | Distal (>10kb) Multiome | 528 | |
| chr19:43,934,900–43,935,680 | 15 bp | At TSS Multiome | 775 | |
| chr19:43,950,951–43,951,533 | 15.9 kb | Distal (>10kb) Multiome | 758 | |
| chr19:43,983,881–43,984,809 | 48.9 kb | Distal (>10kb) Multiome | 634 | |
| chr19:44,002,334–44,003,562 | 67.6 kb | Distal (>10kb) Multiome | 726 | |
| chr19:44,025,169–44,025,638 | 90.1 kb | Distal (>10kb) Multiome | 531 | |
| chr19:44,051,566–44,052,404 | 116.7 kb | Distal (>10kb) Multiome | 706 | |
| chr19:44,071,747–44,072,437 | 136.8 kb | Distal (>10kb) Multiome | 678 | |
| chr19:44,093,936–44,095,205 | 159.0 kb | Distal (>10kb) Multiome | 671 | |
| chr19:44,112,896–44,114,096 | 178.0 kb | Distal (>10kb) Multiome | 719 | |
| chr19:44,141,264–44,142,208 | 206.3 kb | Distal (>10kb) Multiome | 705 | |
| chr19:44,164,531–44,165,427 | 229.7 kb | Distal (>10kb) Multiome | 754 | |
| chr19:44,207,320–44,207,849 | 272.2 kb | Distal (>10kb) Multiome | 743 | |
| chr19:44,212,226–44,213,003 | 277.2 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the ZNF45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.