Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic forelimb morphogenesis; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF358. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF358 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF358, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,293,755–7,294,636 | 221.6 kb | Distal (>10kb) Multiome | 668 | |
| chr19:7,394,774–7,395,629 | 121.0 kb | Distal (>10kb) Multiome | 601 | |
| chr19:7,482,657–7,483,489 | 33.0 kb | Distal (>10kb) Multiome | 201 | |
| chr19:7,488,712–7,489,463 | 27.0 kb | Distal (>10kb) Multiome | 542 | |
| chr19:7,500,843–7,501,401 | 14.9 kb | Distal (>10kb) Multiome | 556 | |
| chr19:7,505,850–7,507,270 | 9.6 kb | Proximal (<10kb) Multiome | 516 | |
| chr19:7,507,812–7,508,356 | 8.0 kb | Proximal (<10kb) Multiome | 168 | |
| chr19:7,512,387–7,512,812 | 3.3 kb | Proximal (<10kb) | 95 | |
| chr19:7,515,778–7,516,198 | at TSS | At TSS | 463 | |
| chr19:7,522,263–7,523,208 | 6.5 kb | Proximal (<10kb) Multiome | 917 | |
| chr19:7,533,976–7,536,472 | 17.9 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 35.3 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 39.2 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 79.7 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 113.6 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 121.0 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 164.7 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the ZNF358 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.