Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF280D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF280D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF280D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:56,464,770–56,465,573 | 268.4 kb | Distal (>10kb) Multiome | 565 | |
| chr15:56,537,662–56,538,339 | 195.5 kb | Distal (>10kb) Multiome | 170 | |
| chr15:56,730,705–56,731,221 | 2.4 kb | Proximal (<10kb) | 24 | |
| chr15:56,732,155–56,732,493 | 1.1 kb | Proximal (<10kb) | 125 | |
| chr15:56,732,731–56,733,957 | 131 bp | At TSS Multiome | 919 | |
| chr15:56,758,979–56,759,508 | 25.6 kb | Distal (>10kb) Multiome | 183 | |
| chr15:56,886,886–56,888,067 | 153.8 kb | Distal (>10kb) Multiome | 1086 | |
| chr15:56,917,829–56,920,157 | 184.9 kb | Distal (>10kb) Multiome | 1031 |
Genomic view of the ZNF280D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.