This gene is imprinted in a tissue-specific manner with preferential expression in the testis, and encodes a zinc finger protein that belongs to a family of zinc finger transcription factors. The encoded protein contains an N-terminal SRE-ZBP, Ctfin51, AW-1, and Number 18 (SCAN) domain, a kruppel-associated box A (KRABA) domain, and four C-terminal zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for ZNF215. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF215 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF215, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,629,672–6,631,067 | 296.0 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 270.7 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 243.0 kb | Distal (>10kb) Multiome | 950 | |
| chr11:6,925,579–6,927,200 | 76 bp | At TSS Multiome | 584 | |
| chr11:6,927,323–6,927,601 | 901 bp | At TSS | 64 | |
| chr11:7,019,692–7,020,997 | 94.0 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the ZNF215 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.