This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for ZNF195. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF195 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF195, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:3,091,645–3,092,317 | 287.2 kb | Distal (>10kb) Multiome | 449 | |
| chr11:3,148,512–3,149,454 | 230.2 kb | Distal (>10kb) Multiome | 152 | |
| chr11:3,160,043–3,161,026 | 218.7 kb | Distal (>10kb) Multiome | 283 | |
| chr11:3,164,925–3,165,485 | 213.9 kb | Distal (>10kb) Multiome | 326 | |
| chr11:3,378,728–3,379,430 | 5 bp | At TSS Multiome | 821 | |
| chr11:3,380,404–3,381,449 | 1.7 kb | Proximal (<10kb) Multiome | 195 | |
| chr11:3,421,770–3,423,686 | 43.7 kb | Distal (>10kb) Multiome | 328 | |
| chr11:3,580,829–3,581,470 | 202.1 kb | Distal (>10kb) Multiome | 80 | |
| chr11:3,614,331–3,614,934 | 235.4 kb | Distal (>10kb) Multiome | 150 | |
| chr11:3,641,420–3,643,023 | 263.0 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the ZNF195 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.