Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for ZNF180. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF180 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF180, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,207,320–44,207,849 | 293.0 kb | Distal (>10kb) Multiome | 743 | |
| chr19:44,212,226–44,213,003 | 288.0 kb | Distal (>10kb) Multiome | 758 | |
| chr19:44,259,722–44,260,198 | 240.6 kb | Distal (>10kb) Multiome | 622 | |
| chr19:44,304,672–44,305,404 | 195.5 kb | Distal (>10kb) Multiome | 703 | |
| chr19:44,356,364–44,357,093 | 143.8 kb | Distal (>10kb) Multiome | 406 | |
| chr19:44,499,680–44,500,955 | 18 bp | At TSS Multiome | 1007 | |
| chr19:44,643,571–44,644,620 | 143.4 kb | Distal (>10kb) Multiome | 710 | |
| chr19:44,747,085–44,747,789 | 247.0 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,757,112–44,758,480 | 256.9 kb | Distal (>10kb) Multiome | 209 | |
| chr19:44,758,633–44,759,104 | 258.4 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 270.2 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 277.4 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 300.1 kb | Distal (>10kb) Multiome | 508 |
Genomic view of the ZNF180 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.