Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF169. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF169 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF169, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:94,030,363–94,031,139 | 228.5 kb | Distal (>10kb) Multiome | 869 | |
| chr9:94,165,559–94,167,324 | 92.5 kb | Distal (>10kb) Multiome | 1085 | |
| chr9:94,250,394–94,250,997 | 8.5 kb | Proximal (<10kb) Multiome | 81 | |
| chr9:94,259,139–94,259,781 | 7 bp | At TSS Multiome | 663 | |
| chr9:94,265,485–94,266,084 | 6.2 kb | Proximal (<10kb) | 31 | |
| chr9:94,374,230–94,375,026 | 115.2 kb | Distal (>10kb) Multiome | 332 | |
| chr9:94,552,994–94,555,388 | 295.5 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the ZNF169 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.