Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF146. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF146 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF146, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,931,342–35,932,167 | 283.4 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 278.7 kb | Distal (>10kb) Multiome | 417 | |
| chr19:35,986,945–35,987,622 | 227.8 kb | Distal (>10kb) Multiome | 363 | |
| chr19:35,994,796–35,995,940 | 219.9 kb | Distal (>10kb) Multiome | 897 | |
| chr19:36,008,519–36,009,006 | 206.3 kb | Distal (>10kb) Multiome | 427 | |
| chr19:36,013,972–36,014,810 | 200.7 kb | Distal (>10kb) Multiome | 623 | |
| chr19:36,032,424–36,033,187 | 182.2 kb | Distal (>10kb) Multiome | 179 | |
| chr19:36,053,782–36,055,591 | 160.6 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:36,113,981–36,116,196 | 99.8 kb | Distal (>10kb) Multiome | 1052 | |
| chr19:36,127,575–36,128,707 | 87.1 kb | Distal (>10kb) Multiome | 942 | |
| chr19:36,139,425–36,141,811 | 73.8 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:36,160,493–36,161,405 | 54.2 kb | Distal (>10kb) Multiome | 94 | |
| chr19:36,214,162–36,215,543 | 255 bp | At TSS Multiome | 1008 | |
| chr19:36,245,106–36,245,849 | 30.3 kb | Distal (>10kb) Multiome | 153 | |
| chr19:36,331,415–36,332,377 | 116.7 kb | Distal (>10kb) Multiome | 372 | |
| chr19:36,378,606–36,379,573 | 164.0 kb | Distal (>10kb) Multiome | 839 | |
| chr19:36,418,146–36,419,031 | 203.6 kb | Distal (>10kb) Multiome | 638 | |
| chr19:36,488,856–36,490,274 | 274.5 kb | Distal (>10kb) Multiome | 991 |
Genomic view of the ZNF146 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.