The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for ZNF141. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF141 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF141, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:124,212–125,389 | 213.3 kb | Distal (>10kb) Multiome | 490 | |
| chr4:212,417–212,910 | 125.1 kb | Distal (>10kb) Multiome | 155 | |
| chr4:304,967–305,746 | 32.3 kb | Distal (>10kb) Multiome | 151 | |
| chr4:330,203–330,371 | 7.4 kb | Proximal (<10kb) | 12 | |
| chr4:336,352–338,341 | 138 bp | At TSS Multiome | 493 | |
| chr4:473,613–474,432 | 136.4 kb | Distal (>10kb) Multiome | 745 | |
| chr4:498,731–499,543 | 161.4 kb | Distal (>10kb) Multiome | 869 | |
| chr4:575,294–576,132 | 237.6 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the ZNF141 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.