Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF131. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF131 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF131, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:42,811,575–42,812,593 | 253.1 kb | Distal (>10kb) Multiome | 702 | |
| chr5:42,813,381–42,813,999 | 251.4 kb | Distal (>10kb) Multiome | 122 | |
| chr5:42,893,601–42,894,516 | 171.2 kb | Distal (>10kb) Multiome | 155 | |
| chr5:42,908,461–42,909,511 | 156.2 kb | Distal (>10kb) Multiome | 451 | |
| chr5:43,016,201–43,016,848 | 48.8 kb | Distal (>10kb) Multiome | 194 | |
| chr5:43,017,299–43,018,875 | 47.1 kb | Distal (>10kb) Multiome | 870 | |
| chr5:43,024,983–43,026,034 | 39.6 kb | Distal (>10kb) Multiome | 130 | |
| chr5:43,041,652–43,043,529 | 23.0 kb | Distal (>10kb) Multiome | 897 | |
| chr5:43,063,696–43,064,191 | 983 bp | At TSS | 231 | |
| chr5:43,064,252–43,065,217 | 209 bp | At TSS Multiome | 959 | |
| chr5:43,065,406–43,065,552 | 231 bp | At TSS | 136 | |
| chr5:43,065,881–43,067,664 | 1.5 kb | Proximal (<10kb) Multiome | 928 | |
| chr5:43,073,946–43,074,322 | 8.8 kb | Proximal (<10kb) | 247 | |
| chr5:43,105,415–43,106,204 | 40.7 kb | Distal (>10kb) Multiome | 820 | |
| chr5:43,110,893–43,111,299 | 9.6 kb | Proximal (<10kb) | 143 | |
| chr5:43,120,453–43,122,435 | 56.2 kb | Distal (>10kb) Multiome | 1097 | |
| chr5:43,191,656–43,192,908 | 127.0 kb | Distal (>10kb) Multiome | 475 | |
| chr5:43,312,549–43,314,340 | 248.4 kb | Distal (>10kb) Multiome | 954 | |
| chr5:43,348,196–43,348,656 | 283.2 kb | Distal (>10kb) Multiome | 141 | |
| chr5:43,396,804–43,397,322 | 332.0 kb | Distal (>10kb) Multiome HiCAR | 340 | |
| chr5:43,416,225–43,416,784 | 351.3 kb | Distal (>10kb) Multiome | 263 |
Genomic view of the ZNF131 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.