This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ZNF124. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF124 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF124, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:246,931,032–246,932,682 | 240.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr1:247,007,420–247,008,623 | 164.0 kb | Distal (>10kb) Multiome | 629 | |
| chr1:247,078,252–247,079,771 | 93.2 kb | Distal (>10kb) Multiome | 817 | |
| chr1:247,089,108–247,090,336 | 82.3 kb | Distal (>10kb) Multiome | 197 | |
| chr1:247,103,830–247,105,264 | 67.6 kb | Distal (>10kb) Multiome | 878 | |
| chr1:247,110,957–247,112,601 | 59.9 kb | Distal (>10kb) Multiome | 790 | |
| chr1:247,118,927–247,119,515 | 52.9 kb | Distal (>10kb) Multiome | 252 | |
| chr1:247,210,163–247,211,257 | 38.8 kb | Distal (>10kb) Multiome | 764 | |
| chr1:247,330,646–247,333,480 | 159.9 kb | Distal (>10kb) Multiome | 839 | |
| chr1:247,347,704–247,348,357 | 176.0 kb | Distal (>10kb) Multiome | 165 | |
| chr1:247,356,823–247,358,156 | 185.2 kb | Distal (>10kb) Multiome | 296 | |
| chr1:247,376,539–247,377,867 | 204.9 kb | Distal (>10kb) Multiome | 164 | |
| chr1:247,389,944–247,390,543 | 218.3 kb | Distal (>10kb) Multiome | 451 | |
| chr1:247,448,083–247,448,740 | 276.4 kb | Distal (>10kb) Multiome | 246 | |
| chr1:248,825,287–248,827,024 | 1654.1 kb | Distal (>10kb) Multiome HiCAR | 866 | |
| chr1:248,905,646–248,907,461 | 1734.4 kb | Distal (>10kb) Multiome HiCAR | 1045 |
Genomic view of the ZNF124 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.