ZNF117

zinc finger protein 117 | H-plk, HPF9

This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Readthrough transcription occurs between this gene and the upstream endogenous retrovirus group 3 member 1 (ERV3-1) locus, and may result in additional transcript variants encoding the zinc finger protein. [provided by RefSeq, Jan 2017]

Member of: DE-8 DE-8.9 Developmental clusters: GC6

Biological processes 8 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZNF117 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF117. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF117 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF117

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF117, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:64,793,972–64,795,082	212.3 kb	Distal (>10kb) Multiome	726
chr7:64,887,970–64,889,709	118.4 kb	Distal (>10kb) Multiome	308
chr7:64,902,559–64,903,772	103.5 kb	Distal (>10kb) Multiome	497
chr7:64,998,057–64,998,217	8.5 kb	Proximal (<10kb)	133
chr7:65,006,175–65,006,968	17 bp	At TSS Multiome	666
chr7:65,037,736–65,039,147	31.5 kb	Distal (>10kb) Multiome	335
chr7:65,080,759–65,081,624	74.6 kb	Distal (>10kb) Multiome	273
chr7:65,233,376–65,233,924	227.0 kb	Distal (>10kb) Multiome	61
chr7:65,239,449–65,240,350	233.2 kb	Distal (>10kb) Multiome	420
chr7:65,251,663–65,252,869	245.6 kb	Distal (>10kb) Multiome	690
chr7:65,268,929–65,270,162	262.6 kb	Distal (>10kb) Multiome	581

Genome Browser

Genomic view of the ZNF117 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.