ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ZMYND19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZMYND19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZMYND19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,294,859–137,296,916 | 295.0 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 288.0 kb | Distal (>10kb) Multiome | 790 | |
| chr9:137,316,104–137,316,916 | 274.2 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 183.4 kb | Distal (>10kb) Multiome | 427 | |
| chr9:137,422,664–137,424,024 | 167.2 kb | Distal (>10kb) Multiome | 896 | |
| chr9:137,441,270–137,441,970 | 148.9 kb | Distal (>10kb) Multiome | 568 | |
| chr9:137,453,153–137,455,543 | 136.5 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 131.1 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 128.6 kb | Distal (>10kb) Multiome | 284 | |
| chr9:137,551,136–137,552,512 | 38.8 kb | Distal (>10kb) Multiome | 756 | |
| chr9:137,578,523–137,579,553 | 11.6 kb | Distal (>10kb) Multiome | 910 | |
| chr9:137,589,526–137,591,323 | 101 bp | At TSS Multiome | 623 | |
| chr9:137,604,440–137,607,003 | 14.9 kb | Distal (>10kb) Multiome | 675 | |
| chr9:137,618,064–137,619,880 | 28.4 kb | Distal (>10kb) Multiome | 867 | |
| chr9:137,723,975–137,724,439 | 133.7 kb | Distal (>10kb) Multiome | 115 | |
| chr9:137,732,255–137,733,025 | 142.1 kb | Distal (>10kb) Multiome | 20 | |
| chr9:137,851,599–137,852,229 | 261.4 kb | Distal (>10kb) Multiome | 104 | |
| chr9:137,876,903–137,879,307 | 287.1 kb | Distal (>10kb) Multiome | 452 |
Genomic view of the ZMYND19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.