ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
Transcription factors with Perturb-seq knockdown data for ZMIZ2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZMIZ2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZMIZ2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:44,490,144–44,491,030 | 257.9 kb | Distal (>10kb) Multiome | 996 | |
| chr7:44,573,627–44,574,398 | 174.6 kb | Distal (>10kb) Multiome | 885 | |
| chr7:44,581,475–44,583,147 | 166.2 kb | Distal (>10kb) Multiome HiCAR | 864 | |
| chr7:44,606,125–44,607,487 | 141.8 kb | Distal (>10kb) Multiome | 1043 | |
| chr7:44,748,085–44,749,703 | 39 bp | At TSS Multiome | 665 | |
| chr7:44,795,796–44,797,747 | 48.0 kb | Distal (>10kb) Multiome | 1094 | |
| chr7:44,847,376–44,848,800 | 99.6 kb | Distal (>10kb) Multiome | 990 | |
| chr7:44,884,668–44,886,169 | 137.0 kb | Distal (>10kb) Multiome | 956 | |
| chr7:44,962,460–44,963,298 | 214.3 kb | Distal (>10kb) Multiome | 179 | |
| chr7:44,986,037–44,987,077 | 238.1 kb | Distal (>10kb) Multiome | 748 | |
| chr7:44,999,127–45,000,858 | 251.4 kb | Distal (>10kb) Multiome | 706 | |
| chr7:45,051,984–45,052,624 | 303.7 kb | Distal (>10kb) Multiome | 90 |
Genomic view of the ZMIZ2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.