This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for ZFR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:32,173,339–32,175,075 | 270.5 kb | Distal (>10kb) Multiome | 1090 | |
| chr5:32,287,695–32,288,492 | 156.6 kb | Distal (>10kb) Multiome | 161 | |
| chr5:32,312,016–32,313,764 | 131.7 kb | Distal (>10kb) Multiome | 877 | |
| chr5:32,443,333–32,445,482 | 2 bp | At TSS Multiome | 960 | |
| chr5:32,463,190–32,463,817 | 18.9 kb | Distal (>10kb) Multiome | 67 | |
| chr5:32,474,004–32,474,924 | 29.6 kb | Distal (>10kb) Multiome | 130 | |
| chr5:32,500,148–32,500,972 | 55.7 kb | Distal (>10kb) Multiome | 96 | |
| chr5:32,585,030–32,586,359 | 141.0 kb | Distal (>10kb) Multiome | 894 | |
| chr5:32,711,666–32,714,486 | 269.4 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the ZFR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.