Enables histone reader activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ZCWPW1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCWPW1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCWPW1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,148,262–100,149,663 | 279.9 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 269.9 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 261.2 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,171,153–100,171,887 | 257.2 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 251.2 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 161.9 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 158.1 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 156.4 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 92.6 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 46.6 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 253 bp | At TSS Multiome | 1296 | |
| chr7:100,431,643–100,432,380 | 2.9 kb | Proximal (<10kb) | 108 | |
| chr7:100,435,379–100,436,927 | 7.8 kb | Proximal (<10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 22.0 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 50.7 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 55.0 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 110.3 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 114.0 kb | Distal (>10kb) Multiome | 274 | |
| chr7:100,569,177–100,570,642 | 140.9 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 157.7 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 183.5 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 198.1 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 227.7 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 244.8 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 247.2 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 263.2 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 265.6 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 277.2 kb | Distal (>10kb) Multiome | 962 |
Genomic view of the ZCWPW1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.