Enables S-adenosyl-L-methionine binding activity; rRNA (adenine-N6-)-methyltransferase activity; and zinc ion binding activity. Involved in positive regulation of translation and rRNA methylation. Located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZCCHC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCCHC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCCHC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:25,030,155–25,031,590 | 281.9 kb | Distal (>10kb) Multiome | 304 | |
| chr4:25,081,936–25,082,684 | 230.5 kb | Distal (>10kb) Multiome | 92 | |
| chr4:25,131,511–25,132,461 | 180.8 kb | Distal (>10kb) Multiome | 74 | |
| chr4:25,159,654–25,161,108 | 152.3 kb | Distal (>10kb) Multiome | 899 | |
| chr4:25,233,604–25,234,892 | 78.8 kb | Distal (>10kb) Multiome | 812 | |
| chr4:25,312,481–25,313,179 | 43 bp | At TSS Multiome | 951 | |
| chr4:25,313,295–25,313,437 | 501 bp | At TSS | 90 | |
| chr4:25,376,361–25,378,027 | 64.4 kb | Distal (>10kb) Multiome | 760 | |
| chr4:25,585,669–25,586,415 | 273.3 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the ZCCHC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.