Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZC3H6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:112,047,188–112,048,562 | 227.7 kb | Distal (>10kb) Multiome | 275 | |
| chr2:112,053,884–112,054,856 | 220.8 kb | Distal (>10kb) Multiome | 492 | |
| chr2:112,054,956–112,056,432 | 220.4 kb | Distal (>10kb) Multiome | 968 | |
| chr2:112,181,502–112,182,275 | 93.8 kb | Distal (>10kb) Multiome | 174 | |
| chr2:112,254,532–112,255,517 | 20.6 kb | Distal (>10kb) Multiome | 915 | |
| chr2:112,275,156–112,276,567 | 626 bp | At TSS Multiome | 1201 | |
| chr2:112,480,926–112,482,608 | 205.5 kb | Distal (>10kb) Multiome | 860 | |
| chr2:112,541,785–112,542,849 | 266.6 kb | Distal (>10kb) Multiome | 1070 |
Genomic view of the ZC3H6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.