Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in RNA destabilization. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZC3H18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,382,901–88,383,561 | 187.2 kb | Distal (>10kb) Multiome | 166 | |
| chr16:88,452,301–88,456,281 | 114.7 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:88,468,411–88,469,072 | 101.7 kb | Distal (>10kb) Multiome | 251 | |
| chr16:88,533,022–88,535,493 | 36.3 kb | Distal (>10kb) Multiome | 458 | |
| chr16:88,569,589–88,571,104 | 90 bp | At TSS Multiome | 904 | |
| chr16:88,634,178–88,635,155 | 64.2 kb | Distal (>10kb) Multiome | 384 | |
| chr16:88,650,385–88,651,684 | 80.7 kb | Distal (>10kb) Multiome | 890 | |
| chr16:88,662,399–88,664,138 | 92.8 kb | Distal (>10kb) Multiome | 943 | |
| chr16:88,686,082–88,687,017 | 116.1 kb | Distal (>10kb) Multiome | 675 | |
| chr16:88,705,859–88,706,820 | 136.0 kb | Distal (>10kb) Multiome | 838 | |
| chr16:88,737,237–88,737,815 | 167.1 kb | Distal (>10kb) Multiome | 619 | |
| chr16:88,769,688–88,770,137 | 199.4 kb | Distal (>10kb) Multiome | 282 | |
| chr16:88,770,700–88,771,325 | 200.7 kb | Distal (>10kb) Multiome | 668 | |
| chr16:88,784,542–88,785,880 | 215.0 kb | Distal (>10kb) Multiome | 811 | |
| chr16:88,802,766–88,805,068 | 233.3 kb | Distal (>10kb) Multiome | 881 | |
| chr16:88,810,968–88,812,892 | 241.7 kb | Distal (>10kb) Multiome | 1059 | |
| chr16:88,856,080–88,858,003 | 286.6 kb | Distal (>10kb) Multiome | 885 |
Genomic view of the ZC3H18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.