Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for YPEL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YPEL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YPEL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:29,900,667–29,901,861 | 245.7 kb | Distal (>10kb) Multiome | 222 | |
| chr2:29,919,939–29,922,298 | 225.2 kb | Distal (>10kb) Multiome | 520 | |
| chr2:30,146,037–30,148,505 | 212 bp | At TSS Multiome | 973 | |
| chr2:30,149,592–30,150,011 | 2.7 kb | Proximal (<10kb) | 286 | |
| chr2:30,152,494–30,152,682 | 5.6 kb | Proximal (<10kb) | 17 | |
| chr2:30,191,616–30,192,270 | 45.1 kb | Distal (>10kb) Multiome | 256 | |
| chr2:30,230,493–30,233,101 | 85.5 kb | Distal (>10kb) Multiome | 678 | |
| chr2:30,290,483–30,291,069 | 143.9 kb | Distal (>10kb) Multiome | 341 | |
| chr2:30,334,726–30,336,025 | 188.3 kb | Distal (>10kb) Multiome | 296 | |
| chr2:30,446,921–30,447,966 | 300.4 kb | Distal (>10kb) Multiome | 993 |
Genomic view of the YPEL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.