This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for YKT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YKT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YKT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:43,905,962–43,907,078 | 294.4 kb | Distal (>10kb) Multiome | 557 | |
| chr7:43,926,113–43,927,072 | 274.5 kb | Distal (>10kb) Multiome | 1004 | |
| chr7:43,985,975–43,986,501 | 214.7 kb | Distal (>10kb) Multiome | 113 | |
| chr7:44,018,938–44,019,667 | 181.8 kb | Distal (>10kb) Multiome | 564 | |
| chr7:44,038,952–44,039,494 | 161.8 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,044,335–44,045,323 | 156.3 kb | Distal (>10kb) Multiome | 832 | |
| chr7:44,063,611–44,064,251 | 137.0 kb | Distal (>10kb) Multiome HiCAR | 121 | |
| chr7:44,065,163–44,066,086 | 135.1 kb | Distal (>10kb) Multiome HiCAR | 198 | |
| chr7:44,081,995–44,083,183 | 118.3 kb | Distal (>10kb) Multiome | 909 | |
| chr7:44,103,745–44,105,419 | 96.7 kb | Distal (>10kb) Multiome | 267 | |
| chr7:44,112,627–44,113,466 | 88.0 kb | Distal (>10kb) Multiome | 237 | |
| chr7:44,123,183–44,124,199 | 77.4 kb | Distal (>10kb) Multiome | 814 | |
| chr7:44,145,408–44,146,956 | 54.8 kb | Distal (>10kb) Multiome HiCAR | 347 | |
| chr7:44,196,465–44,196,673 | 4.3 kb | Proximal (<10kb) | 127 | |
| chr7:44,200,748–44,201,465 | 48 bp | At TSS Multiome | 738 | |
| chr7:44,218,223–44,218,706 | 17.4 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,275,748–44,276,529 | 75.2 kb | Distal (>10kb) Multiome | 146 | |
| chr7:44,309,084–44,310,124 | 108.8 kb | Distal (>10kb) Multiome | 263 | |
| chr7:44,325,052–44,325,687 | 124.4 kb | Distal (>10kb) Multiome | 118 | |
| chr7:44,490,144–44,491,030 | 289.7 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the YKT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.