The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for XPO6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPO6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPO6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:27,867,450–27,867,928 | 344.2 kb | Distal (>10kb) Multiome | 306 | |
| chr16:28,146,569–28,147,015 | 9.0 kb | Proximal (<10kb) | 38 | |
| chr16:28,204,725–28,204,985 | 6.5 kb | Proximal (<10kb) | 26 | |
| chr16:28,211,165–28,212,644 | 98 bp | At TSS Multiome | 960 | |
| chr16:28,267,361–28,267,924 | 55.6 kb | Distal (>10kb) Multiome | 36 | |
| chr16:28,277,564–28,278,417 | 66.0 kb | Distal (>10kb) Multiome | 598 | |
| chr16:28,291,632–28,293,697 | 81.6 kb | Distal (>10kb) Multiome | 578 | |
| chr16:28,491,428–28,492,451 | 280.1 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the XPO6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.