XPO5

exportin 5 | KIAA1291

This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

Member of: DE-5 Developmental clusters: GC4

Biological processes 37 terms

RISC complex (GO:0016442)RISC complex binding (GO:1905172)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA export from nucleus (GO:0006405)RNA nuclear export complex (GO:0042565)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)intracellular protein transport (GO:0006886)mRNA binding (GO:0003729)miRNA metabolic process (GO:0010586)nuclear export signal receptor activity (GO:0005049)nuclear export signal receptor activity (GO:0005049)nuclear export signal receptor activity (GO:0005049)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)pre-miRNA binding (GO:0070883)pre-miRNA binding (GO:0070883)pre-miRNA binding (GO:0070883)pre-miRNA export from nucleus (GO:0035281)pre-miRNA export from nucleus (GO:0035281)pre-miRNA export from nucleus (GO:0035281)protein binding (GO:0005515)protein export from nucleus (GO:0006611)protein export from nucleus (GO:0006611)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)tRNA binding (GO:0000049)

Expression (TPM)

TFs regulating XPO5 0 TFs

Transcription factors with Perturb-seq knockdown data for XPO5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPO5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to XPO5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPO5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:43,285,054–43,285,508	290.6 kb	Distal (>10kb) Multiome	68
chr6:43,308,219–43,309,149	267.2 kb	Distal (>10kb) Multiome	462
chr6:43,368,714–43,370,143	206.3 kb	Distal (>10kb) Multiome	909
chr6:43,426,936–43,428,340	148.3 kb	Distal (>10kb) Multiome	919
chr6:43,454,362–43,454,991	121.3 kb	Distal (>10kb) Multiome	686
chr6:43,477,347–43,478,043	98.4 kb	Distal (>10kb) Multiome	747
chr6:43,506,605–43,507,204	69.1 kb	Distal (>10kb) Multiome	474
chr6:43,509,337–43,511,016	65.6 kb	Distal (>10kb) Multiome	734
chr6:43,516,463–43,517,515	59.0 kb	Distal (>10kb) Multiome	904
chr6:43,575,269–43,576,483	78 bp	At TSS Multiome	1044
chr6:43,628,488–43,630,447	54.2 kb	Distal (>10kb) Multiome	1157
chr6:43,635,496–43,636,104	59.8 kb	Distal (>10kb) Multiome	941
chr6:43,644,712–43,645,902	69.3 kb	Distal (>10kb) Multiome	255
chr6:43,667,273–43,667,900	91.4 kb	Distal (>10kb) Multiome	625
chr6:43,667,997–43,668,873	92.5 kb	Distal (>10kb) Multiome	664
chr6:43,695,239–43,695,940	119.7 kb	Distal (>10kb) Multiome	207
chr6:43,702,335–43,703,403	127.0 kb	Distal (>10kb) Multiome	713
chr6:43,706,840–43,708,370	132.0 kb	Distal (>10kb) Multiome	307
chr6:43,739,421–43,740,065	163.8 kb	Distal (>10kb) Multiome	175
chr6:43,769,188–43,772,162	194.0 kb	Distal (>10kb) Multiome	1112
chr6:43,774,651–43,775,250	199.0 kb	Distal (>10kb) Multiome	440

Genome Browser

Genomic view of the XPO5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.