The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for XPC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:13,879,719–13,881,081 | 298.0 kb | Distal (>10kb) Multiome | 324 | |
| chr3:13,894,956–13,896,282 | 283.1 kb | Distal (>10kb) Multiome HiCAR | 410 | |
| chr3:13,896,386–13,897,098 | 281.8 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr3:13,947,416–13,948,575 | 230.7 kb | Distal (>10kb) Multiome | 105 | |
| chr3:13,950,690–13,951,954 | 227.3 kb | Distal (>10kb) Multiome | 157 | |
| chr3:14,121,816–14,122,532 | 56.5 kb | Distal (>10kb) Multiome | 97 | |
| chr3:14,124,108–14,126,323 | 53.7 kb | Distal (>10kb) Multiome | 1032 | |
| chr3:14,178,020–14,179,126 | 68 bp | At TSS Multiome | 960 | |
| chr3:14,216,206–14,216,677 | 37.8 kb | Distal (>10kb) Multiome | 226 | |
| chr3:14,232,409–14,233,221 | 54.2 kb | Distal (>10kb) Multiome | 527 | |
| chr3:14,272,392–14,272,931 | 94.1 kb | Distal (>10kb) Multiome | 132 | |
| chr3:14,319,426–14,320,088 | 141.2 kb | Distal (>10kb) Multiome | 332 | |
| chr3:14,401,899–14,403,672 | 223.9 kb | Distal (>10kb) Multiome | 895 | |
| chr3:14,412,856–14,413,790 | 234.8 kb | Distal (>10kb) Multiome | 270 | |
| chr3:14,463,118–14,463,686 | 284.8 kb | Distal (>10kb) Multiome HiCAR | 134 |
Genomic view of the XPC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.