Predicted to act upstream of or within corpus callosum development and ventricular system development. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR89. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR89 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR89, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:62,168,293–62,169,601 | 1472.9 kb | Distal (>10kb) Multiome HiCAR | 172 | |
| chr14:63,362,371–63,363,083 | 279.2 kb | Distal (>10kb) Multiome | 52 | |
| chr14:63,542,200–63,544,165 | 98.4 kb | Distal (>10kb) Multiome | 829 | |
| chr14:63,641,240–63,642,923 | 117 bp | At TSS Multiome | 1029 | |
| chr14:63,727,188–63,728,615 | 86.2 kb | Distal (>10kb) Multiome | 737 | |
| chr14:63,852,350–63,854,165 | 211.1 kb | Distal (>10kb) Multiome | 591 | |
| chr14:63,891,140–63,891,876 | 249.6 kb | Distal (>10kb) Multiome | 157 |
Genomic view of the WDR89 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.