WDR82
WD repeat domain 82 | MST107, MSTP107, PRO2730, PRO34047, SWD2, WDR82A, TMEM113

TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

Member of: DE-7 DE-7.3
Biological processes 24 terms
PTW/PP1 phosphatase complex (GO:0072357)RNA polymerase II promoter clearance (GO:0001111)Set1C/COMPASS complex (GO:0048188)Set1C/COMPASS complex (GO:0048188)chromatin (GO:0000785)chromatin binding (GO:0003682)chromatin binding (GO:0003682)chromosome (GO:0005694)chromosome, telomeric region (GO:0000781)cytoplasm (GO:0005737)histone methyltransferase complex (GO:0035097)lncRNA binding (GO:0106222)lncRNA catabolic process (GO:0110064)lncRNA catabolic process (GO:0110064)negative regulation of DNA-templated transcription, elongation (GO:0032785)negative regulation of DNA-templated transcription, elongation (GO:0032785)negative regulation of lncRNA transcription (GO:0140744)negative regulation of lncRNA transcription (GO:0140744)nuclear RNA surveillance (GO:0071027)nuclear RNA surveillance (GO:0071027)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)protein binding (GO:0005515)
Expression (TPM)
WDR82 — as a Regulated Gene

TFs regulating WDR82 0 TFs

Transcription factors with Perturb-seq knockdown data for WDR82. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR82 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to WDR82

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR82, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:51,982,506–51,983,633 304.8 kb Distal (>10kb) Multiome 933
chr3:51,990,597–51,991,772 297.0 kb Distal (>10kb) Multiome 145
chr3:51,995,468–51,996,121 292.1 kb Distal (>10kb) Multiome 938
chr3:52,001,516–52,001,992 286.3 kb Distal (>10kb) Multiome 448
chr3:52,055,881–52,058,048 230.6 kb Distal (>10kb) Multiome 937
chr3:52,128,194–52,128,700 159.6 kb Distal (>10kb) Multiome 376
chr3:52,153,766–52,155,196 133.4 kb Distal (>10kb) Multiome 896
chr3:52,197,554–52,198,856 89.9 kb Distal (>10kb) Multiome 731
chr3:52,238,767–52,239,716 48.8 kb Distal (>10kb) Multiome 763
chr3:52,245,446–52,246,450 42.1 kb Distal (>10kb) Multiome HiCAR 553
chr3:52,277,664–52,279,184 9.3 kb Proximal (<10kb) Multiome 844
chr3:52,287,499–52,288,336 91 bp At TSS Multiome 778
chr3:52,409,430–52,411,187 122.3 kb Distal (>10kb) Multiome HiCAR 813
chr3:52,444,941–52,445,411 157.1 kb Distal (>10kb) Multiome 426
chr3:52,455,213–52,455,878 167.5 kb Distal (>10kb) Multiome 630
chr3:52,518,607–52,519,389 231.0 kb Distal (>10kb) Multiome 176
chr3:52,533,486–52,535,316 245.9 kb Distal (>10kb) Multiome 648
chr3:52,536,232–52,537,450 248.5 kb Distal (>10kb) Multiome 901

Genome Browser

Genomic view of the WDR82 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:51,972,506 – 52,547,450
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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