Predicted to enable signaling adaptor activity. Involved in cellular response to amino acid starvation and positive regulation of TORC1 signaling. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR59. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR59 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR59, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:74,700,393–74,701,030 | 284.4 kb | Distal (>10kb) Multiome | 785 | |
| chr16:74,774,151–74,775,199 | 210.3 kb | Distal (>10kb) Multiome | 669 | |
| chr16:74,812,990–74,813,481 | 171.8 kb | Distal (>10kb) Multiome | 680 | |
| chr16:74,866,003–74,866,478 | 118.9 kb | Distal (>10kb) Multiome | 95 | |
| chr16:74,982,469–74,982,949 | 1.9 kb | Proximal (<10kb) | 61 | |
| chr16:74,984,580–74,985,562 | 82 bp | At TSS Multiome | 877 | |
| chr16:74,998,533–75,000,404 | 13.9 kb | Distal (>10kb) Multiome | 884 | |
| chr16:75,110,910–75,111,744 | 126.3 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr16:75,148,292–75,149,298 | 163.6 kb | Distal (>10kb) Multiome | 970 | |
| chr16:75,250,387–75,252,500 | 266.6 kb | Distal (>10kb) Multiome | 811 | |
| chr16:75,265,114–75,266,526 | 281.0 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the WDR59 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.