The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for WDR48. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR48 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR48, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:39,051,625–39,052,625 | 110 bp | At TSS Multiome | 881 | |
| chr3:39,106,596–39,108,201 | 55.6 kb | Distal (>10kb) Multiome | 754 | |
| chr3:39,150,367–39,155,021 | 99.1 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:39,177,458–39,178,406 | 126.0 kb | Distal (>10kb) Multiome | 531 | |
| chr3:39,180,469–39,181,324 | 129.0 kb | Distal (>10kb) Multiome | 541 | |
| chr3:39,288,216–39,288,885 | 236.5 kb | Distal (>10kb) Multiome | 463 |
Genomic view of the WDR48 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.