Enables RNA binding activity. Involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Located in fibrillar center. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:28,594,185–28,594,811 | 300.1 kb | Distal (>10kb) Multiome | 431 | |
| chr2:28,684,184–28,684,644 | 210.3 kb | Distal (>10kb) Multiome | 193 | |
| chr2:28,751,058–28,752,579 | 142.9 kb | Distal (>10kb) Multiome | 1022 | |
| chr2:28,810,346–28,811,351 | 83.9 kb | Distal (>10kb) Multiome | 393 | |
| chr2:28,869,665–28,870,899 | 24.3 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:28,894,052–28,895,454 | 74 bp | At TSS Multiome | 992 | |
| chr2:29,052,737–29,054,280 | 158.8 kb | Distal (>10kb) Multiome | 269 | |
| chr2:29,055,442–29,056,614 | 161.2 kb | Distal (>10kb) Multiome | 136 | |
| chr2:29,114,952–29,116,267 | 220.7 kb | Distal (>10kb) Multiome | 351 |
Genomic view of the WDR43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.