This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for WDR27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:169,619,312–169,620,680 | 81.7 kb | Distal (>10kb) Multiome | 164 | |
| chr6:169,654,626–169,655,354 | 47.2 kb | Distal (>10kb) Multiome | 165 | |
| chr6:169,656,289–169,657,223 | 45.3 kb | Distal (>10kb) Multiome | 87 | |
| chr6:169,697,211–169,697,416 | 4.7 kb | Proximal (<10kb) | 41 | |
| chr6:169,701,339–169,702,982 | 76 bp | At TSS Multiome | 1050 | |
| chr6:169,723,431–169,725,573 | 22.5 kb | Distal (>10kb) Multiome | 1078 | |
| chr6:169,751,101–169,752,286 | 49.6 kb | Distal (>10kb) Multiome | 1057 | |
| chr6:169,789,764–169,790,892 | 88.3 kb | Distal (>10kb) Multiome | 772 | |
| chr6:169,810,281–169,811,431 | 108.5 kb | Distal (>10kb) Multiome | 326 | |
| chr6:170,552,943–170,554,837 | 852.3 kb | Distal (>10kb) Multiome HiCAR | 1097 |
Genomic view of the WDR27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.