Predicted to be involved in several processes, including filopodium assembly; positive regulation of excitatory synapse assembly; and protein homooligomerization. Predicted to be located in membrane. Predicted to be active in axon; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VSTM5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VSTM5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VSTM5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:93,815,049–93,815,512 | 5.2 kb | Proximal (<10kb) | 16 | |
| chr11:93,817,311–93,818,245 | 2.5 kb | Proximal (<10kb) | 53 | |
| chr11:93,818,526–93,818,988 | 1.8 kb | Proximal (<10kb) | 15 | |
| chr11:93,819,534–93,820,877 | at TSS | At TSS | 61 | |
| chr11:93,828,228–93,828,456 | 7.5 kb | Proximal (<10kb) | 4 | |
| chr11:93,828,564–93,829,177 | 7.8 kb | Proximal (<10kb) | 21 |
Genomic view of the VSTM5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.