This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VSNL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VSNL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VSNL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:17,517,918–17,518,924 | 21.5 kb | Distal (>10kb) Multiome | 501 | |
| chr2:17,538,022–17,538,275 | 1.7 kb | Proximal (<10kb) | 146 | |
| chr2:17,538,445–17,541,363 | 517 bp | At TSS Multiome | 1001 | |
| chr2:17,543,047–17,544,647 | 3.1 kb | Proximal (<10kb) | 336 | |
| chr2:17,545,523–17,545,984 | 5.6 kb | Proximal (<10kb) | 56 | |
| chr2:17,752,946–17,754,742 | 213.9 kb | Distal (>10kb) Multiome | 969 | |
| chr2:17,830,142–17,831,178 | 290.8 kb | Distal (>10kb) Multiome | 569 |
Genomic view of the VSNL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.