Enables calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VPS37B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS37B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS37B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,751,194–122,751,767 | 144.8 kb | Distal (>10kb) Multiome | 128 | |
| chr12:122,752,332–122,753,299 | 143.4 kb | Distal (>10kb) Multiome | 978 | |
| chr12:122,774,223–122,774,865 | 121.6 kb | Distal (>10kb) Multiome | 445 | |
| chr12:122,834,656–122,836,128 | 60.7 kb | Distal (>10kb) Multiome | 514 | |
| chr12:122,895,832–122,896,391 | 24 bp | At TSS Multiome | 774 | |
| chr12:122,965,963–122,966,953 | 70.4 kb | Distal (>10kb) Multiome | 576 | |
| chr12:122,974,115–122,975,704 | 78.8 kb | Distal (>10kb) Multiome | 889 | |
| chr12:122,980,138–122,981,155 | 84.5 kb | Distal (>10kb) Multiome | 817 | |
| chr12:123,049,639–123,050,104 | 153.7 kb | Distal (>10kb) Multiome | 45 | |
| chr12:123,150,285–123,151,740 | 254.9 kb | Distal (>10kb) Multiome | 487 |
Genomic view of the VPS37B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.