This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for VKORC1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VKORC1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VKORC1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:65,731,509–65,732,049 | 141.3 kb | Distal (>10kb) Multiome | 163 | |
| chr7:65,750,398–65,751,615 | 122.1 kb | Distal (>10kb) Multiome | 754 | |
| chr7:65,770,451–65,770,953 | 102.3 kb | Distal (>10kb) Multiome | 335 | |
| chr7:65,872,688–65,874,131 | 35 bp | At TSS Multiome | 352 | |
| chr7:65,880,319–65,880,517 | 7.2 kb | Proximal (<10kb) | 4 | |
| chr7:65,981,748–65,982,750 | 109.2 kb | Distal (>10kb) Multiome | 996 | |
| chr7:66,043,712–66,044,711 | 171.3 kb | Distal (>10kb) Multiome | 136 | |
| chr7:66,075,415–66,076,491 | 202.7 kb | Distal (>10kb) Multiome | 802 | |
| chr7:66,099,334–66,100,655 | 227.1 kb | Distal (>10kb) Multiome | 495 | |
| chr7:66,114,557–66,115,604 | 242.0 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the VKORC1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.